Common brand names:

Abraxane, Onxol, Taxol

Paclitaxel is a natural (though quite toxic) substance derived from the yew tree by taking a naturally present substance from the tree and chemically altering it to form the drug. The resultant drug is administered intravenously. It is used as a chemotherapy drug to treat people with a wide variety of cancers.

Note: Many of the interactions described below, in the text and in the Summary of Interactions, have been reported only for specific chemotherapeutic drugs, and may not apply to other chemotherapeutic drugs. There are many unknowns concerning interactions of nutrients, herbs, and chemotherapy drugs. People receiving chemotherapy who wish to supplement with vitamins, minerals, herbs, or other natural substances should always consult a physician.

Summary of Interactions with Vitamins, Herbs, & Foods

Types of interactions:beneficial= Beneficialadverse= Adversecheck= Check
dnicon_Beneficial May Be Beneficial: Depletion or interference—This medication may deplete these substances from the body or interfere with how they work; extra intake may help replenish them.
Magnesium and Potassium
Lactobacillus GG*
N-Acetyl Cysteine*
Spleen Peptide Extract*
dnicon_Beneficial May Be Beneficial: Side effect reduction and/or prevention—These substances may help reduce the likelihood and/or severity of a potential side effect caused by the medication.
Calcium and Magnesium
Wheat Grass
Fish Oil*
N-Acetyl Cysteine*
Spleen Peptide Extract*
Thymus Extracts*
Vitamin E*
dnicon_Beneficial May Be Beneficial: Supportive interaction—These substances may help this medication work better.
Thymus Extracts
Wheat Grass
Milk Thistle*
dnicon_Avoid Avoid: Reduces drug effectiveness—When taking this medication, avoid these substances as they may decrease the medication's absorption and/or activity in the body.


dnicon_Avoid Avoid: Adverse interaction—When taking this medication, avoid these substances, as the combination may cause undesirable or dangerous interactions.


dnicon_Check Check: Explanation needed—When taking this medication, read the article details and discuss them with your doctor or pharmacist before taking these substances.
N-Acetyl Cysteine*
Vitamin A*
Vitamin A, Vitamin C, and N-Acetyl Cysteine*
Vitamin C*
Vitamin E*
The Drug-Nutrient Interactions table may not include every possible interaction. Taking medicines with meals, on an empty stomach, or with alcohol may influence their effects. For details, refer to the manufacturers’ package information as these are not covered in this table. If you take medications, always discuss the potential risks and benefits of adding a new supplement with your doctor or pharmacist.

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There are some limitations on the information provided in “Nutrient Interactions.” Do NOT rely solely on the information in this article. Please read the disclaimer.

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Information expires December 2020.

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